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Source: www.nature.com

Lignosus rhinocerotis extract ameliorates airway inflammation

December 16, 2023

Allergic asthma is associated with chronic airway inflammation and progressive airway remodelling. The sclerotium of Lignosus rhinocerotis (Cooke) Ryvarden (Tiger Milk mushroom) is used traditionally to treat various illnesses, including asthma in Southeast Asia. This study was carried out to evaluate the effect of Lignosus rhinocerotis extract (LRE) on airway inflammation and remodelling in a chronic model of asthma. The present study investigated the therapeutic effects of LRE on airway inflammation and remodelling in prolonged allergen challenged model in allergic asthma. Female Balb/C mice were sensitised using ovalbumin (OVA) on day 0 and 7, followed by OVA-challenged (3 times/week) for 2, 6 and 10 weeks. LRE (125, 250, 500 mg/kg) were administered by oral gavage one hour after every challenge. One group of mice were left untreated after the final challenge for two weeks. LRE suppressed inflammatory cells and Th2 cytokines (IL-4, IL-5 and IL-13) in BALF and reduced IgE level in the serum. LRE also attenuated eosinophils infiltration and goblet cell hyperplasia in the lung tissues; as well as ameliorated airway remodelling by reducing smooth muscle thickness and reducing the expressions of TGF-β1 and Activin A positive cell in the lung tissues. LRE attenuated airway inflammation and remodelling in the prolonged allergen challenge of allergic asthma model. These findings suggest the therapeutic potential of LRE as an alternative for the management of allergic asthma.

Introduction

Asthma is a chronic respiratory disorder which characterised by pathophysiological symptoms such as hyperresponsiveness, obstruction, remodelling, and inflammation of the airway1. It is a serious public health problem affecting people of all ages2. More than 300 million people are affected globally, with at least 250,000 deaths each year, and its prevalence is increasing, especially in developing countries3. Hence presenting a major public health and socioeconomic burden.

In asthma pathophysiology, a complex combination of genetic, environmental, and immunological factors play role. Read more: https://rb.gy/8j6bu5

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